Although RNA has long been recognized to be a multifunctional molecule with the ability to encode both genetic and structural information, recent insights coupled with technological breakthroughs have reinforced its centrality in biology. Most if not all non-coding RNAs are associated to proteins within so called ribonucleoprotein particles, or RNPs. Non-coding RNAs regulate most biological processes in the cell and are required for cellular homeostasis, and their deregulation underlies a host of important human diseases.
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